Search on: COMPLEMENT FACTOR H 
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Descriptor English:   Complement Factor H 
Descriptor Spanish:   Factor H de Complemento 
Descriptor Portuguese:   Fator H do Complemento 
Synonyms English:   Factor H, Complement
Factor H  
Tree Number:   D12.776.124.486.274.920.325.200
D12.776.124.790.223.200
D12.776.377.715.182.200
Definition English:   An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY). 
Pharmacological Action:   Complement Inactivating Agents
 
History Note English:   93; was COMPLEMENT FACTOR H (NM) 1978-92 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   30775 
Unique Identifier:   D017242 

Occurrence in VHL: 		 

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